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In this blog post, we'll explore what Spravato is, how it works, and why it might be the right choice for you or a loved one. Mainstream Mental Health is excited to announce that we now offer Spravato (esketamine) as a treatment option. This new addition represents a significant advancement in our commitment to providing comprehensive mental health care.
What Is Spravato Prescribed For?
Spravato is primarily used to treat adults with treatment-resistant depression (TRD). TRD is a form of major depressive disorder (MDD) that doesn't respond to at least two different antidepressant treatments. Additionally, Spravato is approved for adults with major depressive disorder who have suicidal thoughts or actions.
How Does Spravato Work in the Body?
Spravato is a nasal spray that contains esketamine, a derivative of ketamine. It works differently from traditional antidepressants. While most antidepressants affect serotonin, norepinephrine, and dopamine, Spravato targets the NMDA (N-methyl-D-aspartate) receptor in the brain. By modulating this receptor, Spravato can rapidly improve mood and symptoms of depression. This rapid action is crucial for those with severe symptoms who need quick relief.
How Is Spravato Different Than Other Treatment Options?
Speed of Action: Traditional antidepressants often take weeks to show effects. Spravato can work within hours to days, providing faster relief.
Mechanism of Action: Unlike SSRIs (Selective Serotonin Reuptake Inhibitors) and other common antidepressants, Spravato works on the glutamate system, offering a new pathway for treating depression.
Administration Method: Spravato is administered as a nasal spray under medical supervision, whereas most antidepressants are taken orally.
What are Spravato's Most Common Off-Label Uses?
While Spravato is primarily approved for TRD and depression with suicidal thoughts, it may be prescribed off-label for other conditions such as:
Anxiety Disorders: Some clinicians may use Spravato to help manage severe anxiety disorders.
PTSD (Post-Traumatic Stress Disorder): Research is ongoing, but some patients with PTSD may benefit from Spravato due to its rapid mood-stabilizing effects.
Why Is Spravato Considered An Advancement In Treatment?
Spravato represents a paradigm shift in how we address severe depression. Its rapid action and different mechanism of targeting the brain's NMDA receptors provide hope for those who have not found relief with traditional treatments. This innovation highlights the importance of continuing to explore new avenues in mental health treatment.
Common Patient Questions About Spravato:
How is Spravato administered? Spravato is a nasal spray given in a clinic under the supervision of a healthcare provider. Patients must stay in the clinic for observation after administration to monitor for any side effects.
How often do I need to take Spravato? The treatment schedule typically involves twice-weekly doses for the first four weeks, followed by weekly doses for the next four weeks, and then maintenance treatments as needed.
Are there side effects? Common side effects include dizziness, dissociation (a feeling of being disconnected from reality), nausea, and increased blood pressure. These are typically monitored by healthcare providers during and after administration.
How quickly will I feel better? Many patients report feeling better within hours to days of their first dose, which is much faster than traditional antidepressants.
Is Spravato covered by insurance? Coverage can vary. It's best to check with your insurance provider to understand your specific benefits and out-of-pocket costs.
By offering Spravato, Mainstream Mental Health continues to provide innovative and effective treatment options tailored to meet the unique needs of our patients. If you or someone you know is struggling with treatment-resistant depression or severe depression with suicidal thoughts, contact us today to see if Spravato might be the right choice for you.
For more detailed information, you can refer to FDA's Spravato page and the Mayo Clinic's article on esketamine.
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